Cancer Immunotherapy Administration Protocol

Pre-Treatment Assessment

Required Baseline Testing

• Complete blood count with differential
• Comprehensive metabolic panel
• Thyroid function tests (TSH, free T4)
• Baseline imaging as indicated
• Autoimmune marker screening

Patient Eligibility Verification

• ECOG performance status ≤2
• Adequate organ function
• No active autoimmune conditions
• No systemic immunosuppression

Administration Protocol

Pre-Medication Requirements

1. Standard Protocol

   • Acetaminophen 650mg PO
   • Consider H1 antagonist for patients with prior reactions

2. Special Circumstances

   • Additional pre-medications based on specific agent and patient history

Administration Process

1. Initial Steps

   • Verify patient identity and consent
   • Review current vital signs
   • Establish IV access

2. Medication Delivery

   • Use dedicated IV line
   • Follow agent-specific infusion rates
   • Monitor vital signs q15min during first infusion

Monitoring Requirements

During Treatment

• Vital signs monitoring schedule
• Infusion reaction assessment
• Documentation requirements

Post-Treatment

• Observation period (minimum 30 minutes)
• Discharge criteria verification
• Follow-up scheduling

Adverse Event Management

Common irAEs

1. Grade 1-2

   • Continue treatment with close monitoring
   • Symptomatic management

2. Grade 3-4

   • Hold treatment
   • Initiate high-dose corticosteroids
   • Follow organ-specific management protocols

Documentation Requirements

• Pre-treatment assessment
• Administration details
• Vital signs
• Adverse events
• Response assessment

Quality Assurance

• Regular protocol review
• Staff competency assessment
• Adverse event tracking
• Outcome monitoring