Standard Chemotherapy Administration Protocol

Pre-Administration Phase

Patient Assessment

• Verify patient identity using two identifiers
• Review current lab results (CBC, CMP)
• Check vital signs
• Assess IV access/port status
• Document weight and height
• Calculate BSA if required

Medication Verification

• Double-check chemotherapy orders against treatment plan
• Verify drug calculations
• Confirm appropriate dose reductions if applicable
• Check for drug-drug interactions

Administration Phase

Safety Measures

1. Don appropriate PPE

   • Chemotherapy-rated gloves
   • Protective gown
   • Face shield when indicated

2. Prepare emergency equipment

   • Spill kit
   • Anaphylaxis kit
   • Emergency medications

Administration Steps

1. Pre-medication protocol

   • Antiemetics as ordered
   • Hydration if required
   • Wait appropriate interval

2. Primary administration

   • Verify patency of access
   • Follow specific drug sequence
   • Monitor infusion rates
   • Document start/stop times

Post-Administration Phase

Monitoring

• Vital signs q15min during first hour
• Assess for immediate reactions
• Monitor IV site/access

Documentation

• Complete drug administration record
• Document patient tolerance
• Record any adverse events
• Update cumulative dose tracking

Special Considerations

Vesicant Administration

• Use central line when possible
• Verify blood return
• Monitor site frequently
• Document assessment findings

Emergency Procedures

• Extravasation protocol
• Hypersensitivity response
• Spill management

Quality Assurance

• Regular competency assessment
• Protocol compliance monitoring
• Documentation audits