Stevens-Johnson Syndrome (SJS)

A Comprehensive Guide to Understanding This Serious Skin Condition

Dermatology

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Last updated: Mar 24, 2025

What is Stevens-Johnson Syndrome?

Stevens-Johnson Syndrome is a rare but serious disorder affecting the skin and mucous membranes. It's considered a medical emergency that usually requires hospitalization.

Key Characteristics

  • Severe blistering of the skin and mucous membranes
  • Painful rash that spreads and peels
  • Fever and flu-like symptoms
  • Can affect eyes, mouth, and internal organs

Common Causes

  • Medication reactions (most common)
    • Antibiotics
    • Anti-seizure medications
    • Pain relievers
  • Infections
  • Rarely, vaccinations

Warning Signs

  1. Unexplained widespread skin pain
  2. Flu-like symptoms
  3. Purple or red rash that spreads
  4. Blistering, especially around mucous membranes
  5. Peeling skin

Treatment Approaches

Immediate Actions

  • Discontinuation of triggering medications
  • Hospitalization for intensive care
  • Wound care and infection prevention

Ongoing Care

  • Fluid and electrolyte management
  • Pain control
  • Specialized wound dressing
  • Eye care if affected

Long-term Outlook

  • Recovery can take weeks to months
  • Possible complications:
    • Eye problems
    • Skin changes
    • Lung damage
  • Regular follow-up care is essential

Prevention

  • Genetic testing if family history exists
  • Avoid known trigger medications
  • Maintain detailed medical history
  • Alert all healthcare providers about previous reactions

When to Seek Emergency Care

Seek immediate medical attention if you experience:

  • Unexplained skin pain
  • Blistering
  • Fever with rash
  • Sore throat with eye burning

Support and Resources

  • Support groups
  • Specialized dermatology care
  • Genetic counseling when appropriate
  • Mental health support during recovery

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