What is Amyloidosis?
Amyloidosis is a rare condition that occurs when abnormal proteins called amyloids build up in your organs and tissues. These protein deposits can interfere with normal organ function and lead to serious health complications.
Types of Amyloidosis
Primary (AL) Amyloidosis
- Most common type in developed countries
- Caused by abnormal plasma cells in bone marrow
- Affects heart, kidneys, liver, and other organs
Secondary (AA) Amyloidosis
- Develops due to chronic inflammatory conditions
- Often affects kidneys and digestive tract
- Related to conditions like rheumatoid arthritis
Hereditary Amyloidosis
- Inherited genetic mutation
- Often affects nerves and heart
- Most common form is ATTR amyloidosis
Common Symptoms
- Fatigue and weakness
- Shortness of breath
- Swelling in legs and ankles
- Numbness or tingling in hands/feet
- Unexplained weight loss
- Heart rhythm problems
Diagnosis
- Blood and urine tests
- Tissue biopsy
- Imaging studies (echocardiogram, MRI)
- Genetic testing for hereditary forms
Treatment Options
Medication-Based Treatments
- Chemotherapy for AL amyloidosis
- Anti-inflammatory drugs
- Targeted therapies
Other Treatments
- Stem cell transplantation
- Organ transplantation if necessary
- Supportive care for symptoms
Living with Amyloidosis
- Regular medical monitoring
- Lifestyle modifications
- Diet and exercise adjustments
- Support group participation
When to Seek Medical Care
Contact your healthcare provider if you experience:
- Severe fatigue
- Difficulty breathing
- Significant swelling
- Unexplained weight loss
- Persistent numbness
Prevention and Management
- Regular check-ups
- Early intervention
- Medication compliance
- Lifestyle modifications
- Stress management