Understanding Parkinson's Disease

A Comprehensive Guide for Patients and Caregivers

Neurology

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Last updated: Mar 24, 2025

What is Parkinson's Disease?

Parkinson's disease (PD) is a progressive neurological disorder that affects movement. It develops when nerve cells in the brain that produce dopamine become impaired or die.

Key Symptoms

Primary Motor Symptoms

  • Tremor - Usually begins in hands; typically occurs at rest
  • Bradykinesia - Slowness of movement
  • Muscle Rigidity - Stiffness in limbs and trunk
  • Postural Instability - Balance problems and falling risk

Non-Motor Symptoms

  • Depression and anxiety
  • Sleep disorders
  • Cognitive changes
  • Loss of smell
  • Speech difficulties

Diagnosis

  • Clinical examination by a neurologist
  • Medical history review
  • Neurological and physical examinations
  • Response to Parkinson's medications

Treatment Options

Medications

  1. Levodopa - Gold standard treatment
  2. Dopamine Agonists - Mimics dopamine effects
  3. MAO-B Inhibitors - Helps preserve dopamine
  4. Anticholinergics - Controls tremors and rigidity

Additional Therapies

  • Physical therapy
  • Occupational therapy
  • Speech therapy
  • Exercise programs

Living with Parkinson's

Lifestyle Modifications

  • Regular exercise
  • Balanced nutrition
  • Adequate rest
  • Stress management
  • Home safety modifications

Support Systems

  • Family and caregiver support
  • Support groups
  • Regular medical follow-up
  • Mental health care

Research and Future

  • Ongoing clinical trials
  • New treatment approaches
  • Genetic research
  • Biomarker studies

When to Contact Your Doctor

  • Worsening symptoms
  • New symptoms
  • Medication side effects
  • Falls or safety concerns

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