Understanding Thrombophilia

A Comprehensive Guide to Blood Clotting Disorders

Vascular Surgery

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Last updated: Mar 24, 2025

What is Thrombophilia?

Thrombophilia is a group of blood disorders that increase the risk of developing blood clots (thrombosis) in blood vessels. These conditions can be inherited or acquired throughout life.

Types of Thrombophilia

Inherited Thrombophilia

  • Factor V Leiden mutation
  • Prothrombin gene mutation
  • Protein C deficiency
  • Protein S deficiency
  • Antithrombin deficiency

Acquired Thrombophilia

  • Antiphospholipid syndrome
  • Cancer-related thrombophilia
  • Pregnancy-associated thrombophilia

Common Symptoms

  • Deep vein thrombosis (DVT)
  • Pulmonary embolism
  • Recurrent miscarriages
  • Unexplained blood clots at a young age
  • Family history of blood clots

Diagnosis

Testing Methods

  1. Blood tests for genetic mutations
  2. Coagulation factor testing
  3. Antibody testing
  4. Family history assessment

Treatment Options

Preventive Measures

  • Blood-thinning medications (anticoagulants)
  • Regular monitoring
  • Lifestyle modifications

Risk Management

  • Avoiding prolonged immobility
  • Staying hydrated
  • Exercise with physician approval
  • Special precautions during pregnancy

When to Seek Medical Attention

  • Sudden leg pain or swelling
  • Chest pain or shortness of breath
  • Unexplained bruising
  • Signs of stroke

Living with Thrombophilia

Daily Management

  • Take medications as prescribed
  • Attend regular check-ups
  • Maintain healthy lifestyle habits
  • Wear medical alert jewelry

Prevention Strategies

  1. Stay active
  2. Maintain healthy weight
  3. Avoid smoking
  4. Follow medication schedule
  5. Regular medical monitoring

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