Understanding Your Migraine Medication Options

A Comprehensive Guide to Acute and Preventive Treatments

Neurology

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Last updated: Mar 24, 2025

Acute Medications (For Immediate Relief)

1. Over-the-Counter Options

  • NSAIDs
    • Ibuprofen (Advil®, Motrin®)
    • Naproxen (Aleve®)
    • Aspirin
  • Acetaminophen (Tylenol®)
  • Combination medications (Excedrin® Migraine)

2. Prescription Options

Triptans

  • Sumatriptan (Imitrex®)
  • Rizatriptan (Maxalt®)
  • Zolmitriptan (Zomig®)

Other Classes

  • Gepants (Ubrelvy®, Nurtec®)
  • Ditans (Reyvow®)
  • Anti-nausea medications

Preventive Medications

1. Traditional Preventive Options

  • Beta-blockers (propranolol, metoprolol)
  • Antidepressants (amitriptyline)
  • Anticonvulsants (topiramate)

2. CGRP Antagonists

  • Monthly injections
  • Oral preventive options

Important Considerations

  • Take medications at first sign of migraine
  • Follow prescribed dosing schedules
  • Keep track of medication use
  • Watch for medication overuse headache
  • Discuss side effects with your doctor

When to Seek Emergency Care

  • Sudden, severe headache
  • Headache with fever or stiff neck
  • Neurological symptoms lasting >1 hour
  • New onset after age 50

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